Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated. Naproxen is effective for the usual rheumatologic indications....

All our body organs are not like the brain, heart or the lungs. Something is also there which we wear on the otside. Skin is our largest organ—adults carry some 8 pounds (3.6 kilograms) and 22 square feet (2 square meters) of it. This fleshy covering does a lot more than make us look presentable....

Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, together with the realization of the significance of time-of-day of drug administration on resultant pharmacodynamic and pharmacokinetic parameters....